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24h尿蛋白对早发型重度子痫前期母婴结局的影响 被引量:7

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摘要 目的:探讨24h尿蛋白定量高低及其变化对早发型重度子痫前期(PE)实施期待治疗母婴结局的影响。方法:回顾分析2008年1月至2013年12月在温州医科大学附属第一医院住院期待治疗并分娩、发病孕周(28^0/7-33^6/7周)的94例重度PE患者的临床资料。根据入院24h尿蛋白定量分为两组:I组〈5g(56例),II组≥5g(38例)。比较两组患者的临床特点及母婴结局。结果:Ⅰ、Ⅱ组患者的期待治疗时间分别为12.6和12.2天,85%患者经保守治疗后24h尿蛋白呈增长趋势。两组孕妇的严重并发症,包括胎盘早剥、HELLP综合征、低蛋白血症、胸腹水、FGR比较,差异无统计学意义(P〉0.05),两组均无DIC、子痫及孕产妇死亡发生。(3)围产儿结局中,出生体重、出生孕周、Apgar评分、NICU住院时间、并发症(颅内出血、支气管肺发育不良、坏死性小肠结肠炎)比较,差异均无统计学意义(P〉0.05);Ⅱ组的RDS发生率及入住NICU高于Ⅰ组,差异有统计学意义(P〈0.05),两组围产儿死亡率均为5%。结论:对早发型重度PE伴蛋白尿的患者,不应将24h尿蛋白量或增长速率作为终止妊娠的单一指标,需结合孕周、临床症状、胎儿成熟度和实验室检查,在母体实施期待疗法条件良好的情况下,尽可能延长孕周以改善围生儿预后。
出处 《现代妇产科进展》 CSCD 北大核心 2015年第1期54-56,共3页 Current Advances In Obstetrics and Gynecology
作者简介 第一作者简介:杨蒙蒙(1989-),女,温州医科大学硕士研究生。主要研究方向:围产医学。 通讯作者Email:zhwm63@126.com
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参考文献12

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