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阴道镜联合TCT及高危型HPV-DNA对宫颈疾病筛查的意义 被引量:8

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摘要 目的探讨阴道镜联合液基薄层细胞学技术及高危型人乳头瘤病毒(HPV)检测对宫颈病变的诊断意义。方法选择宁波妇女儿童医院就诊并行液基薄层细胞学技术(TCT)及高危型HPV-DNA(HC2-HPV DNA)检查的5 579例患者的临床资料,其中TCT结果异常530例,未能明确诊断意义非典型的鳞状细胞(ASCUS)285例,低度鳞状上皮内病变(LSIL)179例,高度鳞状上皮内病变(HSIL)66例,TCT阴性而HPV阳性患者264例,对上述患者行阴道镜下宫颈活检及宫颈管搔刮,以病理结果为"金标准",对结果进行分析。结果病理结果示:宫颈上皮内瘤变(CIN)I级98例,CINII级92例,CINIII级57例,宫颈癌20例,慢性宫颈炎527例。HSIL组的组织学符合率高于LSIL组。阴道镜检查与宫颈活检两种检查对宫颈病变诊断的准确率差异无统计学意义(P〉0.05),阴道镜诊断CIN及宫颈癌的灵敏度0.9567,特异度0.9019,阳性预测值0.8209,阴性预测值0.9779。结论阴道镜联合TCT及HPV可增加CIN和早期宫颈癌的检出率,减少早期病变的漏诊。
作者 王琴 陈惠英
出处 《现代实用医学》 2014年第11期1423-1425,共3页 Modern Practical Medicine
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