期刊文献+

GSTP1、XRCC1基因多态性与结直肠癌个体化治疗的研究进展 预览 被引量:2

GSTP1,XRCC1 Polymorphisms and the Individualized Treatment of Colorectal Cancer
在线阅读 下载PDF
收藏 分享 导出
摘要 近年来,根据肿瘤个体基因特征进行个体化治疗正日益成为国内外学者关注的焦点.对结直肠癌患者进行药物基因组学研究发现,谷胱甘肽转移酶P1(GSTP1)、X线修复交叉互补基因1(XRCC1)、二氢嘧啶脱氢酶基因、甲基四氢叶酸还原酶等基因的多态性可能会影响化疗效果、生存时间和不良反应,可为实施个体化治疗提供了新的预测指标.该文着眼于国内外学者对GSTP1和XRCC1基因多态性的检测和分析,对其研究进展予以综述. In recent yems,individualized treatment according to the characters of tumor individual genes is increasingly becoming the focus of scholars at home and abroad.The study of chemotherapy in colorectal cancer found that the gene polymorphism loci in GSTP1,XRCC1,DPYD,MTHFR may affect the chemotherapy effect,the survival time and adverse reactions,providing a new predictor for the implementation of individualized treatment.Here is to make a review of the research progress in detection and analysis of GSTP1 and XRCC1 polymorphisms.
作者 吴云云 刘鹏飞 陈少骥 WU Yun-yun(Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China) LIU Peng-fei(Wujiang City First People's Hospital Affiliated to Nantong University, Wujiang 215200, China)
出处 《医学综述》 2014年第18期3319-3321,共3页 Medical Recapitulate
关键词 谷胱甘肽转移酶P1 X线修复交叉互补基因 多态性 药物基因组学 结直肠癌 个体化治疗 GSTP1 XRCC1 Gene polymorphisms Pharmacogenomics Colorectal cancer Individualized treatment
  • 相关文献

参考文献36

  • 1Yuan Y,Li MD,Hu HG,et al.Prognostic and survival analysis of837 Chinese colorectal cancer patients[J].World J Gastroenterol,2013,19(17):2650-2659. 被引量:1
  • 2Claret L,Gupta M,Han K,et al.Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer[J].J Clin Oncol,2013,31(17):2110-2114. 被引量:1
  • 3Ohira G,Miyauchi H,Suzuki K,et al.Neoadjuvant chemotherapy for recurrent colorectal cancer[J].Gan To Kagaku Ryoho,2012,39(12):2189-2191. 被引量:1
  • 4Euhus DM,Robinson L.Genetic predisposition syndromes and their management[J].Surg Clin North Am,2013,93(2):341-362. 被引量:1
  • 5Falandry C,Bonnefoy M,Freyer G.Revisiting the frontiers of pharmacogenomics of colon cancer[J].Pharmacogenomics,2011,12(9):1243-1248. 被引量:1
  • 6Lin YL,Liau JY,Yu SC,et al.Oxaliplatin-based chemotherapy might provide longer progression-free survival in KRAS mutant metastatic colorectal cancer[J].Transl Oncol,2013,6(3):363-369. 被引量:1
  • 7Moreau LC,Rajan R,Thirlwell MP,et al.Response to chemotherapy in metastatic colorectal cancer after exposure to oxaliplatin in the adjuvant setting[J].Anticancer Res,2013,33(4):1765-1768. 被引量:1
  • 8Y,Hinoda Y.Genetic and epigenetic changes in colorectal cancer and genetic testing for personalized medicine.[J].Rinsho Byori,2012,60(10):976-981. 被引量:1
  • 9Rwolova M,Smerkova K,Chomoucka J,et al.Glutathione modified CdTe quantum dots as a label for studying DNA interactions with Platinum based cytostatics[J].Electrophoresis,2013,34(6):801-808. 被引量:1
  • 10Tian Z,Li YL,Liu JG.XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population[J].Mol Biol Rep,2013,40(7):4147-4151. 被引量:1

同被引文献44

  • 1蔡乐,朱珠.二氢嘧啶脱氢酶及其与5-氟尿嘧啶疗效和毒性的关系[J].中国药学杂志,2007,42(19):1441-1445. 被引量:6
  • 2Akhlaghpoor S, Aziz-Ahari A, Amoui M, et al. Short-term effectiveness of radiochemoembolization for selected hep- atic metastases with a combination protocol [J]. World J Gastroenterol, 2012,18 (37) : 5249-5259. 被引量:1
  • 3Brudvik KW, Bains S J, Seeberg LT, et al. Aggressive treat- ment of patients with metastaticcolorectal cancer increases survival:a scandinavian single-center experience [J]. HPB Surg, 2013,68( 1 ) : 727095. 被引量:1
  • 4Eichler K, Zangos S, Mack MG, et al. First human study in treatment of unresectable liver metastases from colorectal cancer with irinotecan-loaded beads (DEBIRI)[J]. Int J Oncol, 2012,41(4) : 1213-1220. 被引量:1
  • 5Tai CJ,Wang CK,Tai C J, et al. Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cyto- toxicity of Cisplatin,Doxorubicin,Docetaxel,and 5-Fluo- rouracil in Human Colorectal Carcinoma Cells [J]. Evid Based Complement Ahernat Med, 2013,36 ( 5 ) : 514719. 被引量:1
  • 6Sperling J, Brandhorst D, Schafer T, et al. Liver-directed chemotherapy of cetuximab and bevacizumab in combi- nation with oxaliplatin is more effective to inhibit tumor growth of CC531 colorectal rat liver metastases than sys- temic chemotherapy [J]. Clin Exp Metastasis,2013,30(4) : 447-455. 被引量:1
  • 7王斯琪.紫杉醇及其抗癌作用的研究进展[J].科技促进发展,2009,(6):348. 被引量:1
  • 8Paprottka PM,Schmidt GP,Trumm CG,et al. Changes in normal liver and spleen volume after radioembolization with (90)Y-resin microspheres inmetastatic breast can- cer patients:findings and clinical significance [J]. Car- diovasc Intervent Radiol, 2011,34(5) : 964-72. 被引量:1
  • 9Jiang J, Liang X, Zhou X, et al. ERCC1 expression as a prognostic and predictive factor in patients with non - small cell lung cancer: a meta - analysis[ J]. Mol Biol Rep,2012, 39(6) :6933 -6942. 被引量:1
  • 10Wu J, Lu LY, Yu X. The role of BRCA1 in DNA damage re- sponse [ J 1. Protein Cell,2010,1 ( 2 ): 117 - 123. 被引量:1

引证文献2

二级引证文献4

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈