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云南白药提取物对大鼠实验性牙周炎的治疗作用

Therapeutic effect of the extracts of Yunnan Baiyao on experimental periodontitis in rats
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摘要 目的研究云南白药提取物对大鼠实验性牙周炎的治疗作用。方法采用正畸用钢丝结扎健康SD大鼠左上颌第二磨牙(M2)颈部,并每日喂养10%高糖水,诱导形成大鼠牙周炎模型。挑选造模成功的大鼠分为模型组和云南白药组,另设空白对照组不作任何处理。每2周测定大鼠的临床指标,治疗5周后,处死所有大鼠并取左上颌牙齿制作标本,在体视显微镜下观察并测量牙槽骨吸收情况。结果除牙齿菌斑指数外,治疗后云南白药组各临床指标较模型组均有所下降,且其釉牙骨质界-牙槽嵴顶(CEJ-ABC)距离相较于模型组也明显减小。结论云南白药提取物可改善口腔的临床指标,并缓解实验性牙周炎症状。 OBJECTIVE To study the therapeutic effect of Yunnan Baiyao extracts on experimental periodontitis in rats.METHODS Healthy SD rats'left maxillary second molar (M2)were ligated with orthodontic steel wire and fed with 10%high sugar water daily to induce rat periodontitis model,and the successful models were picked and randomly divided into model group and Yunnan Baiyao group.Another 7rats were not given any treatment as the blank control group.The clinical indicators were measured every 2weeks. After 5weeks of treatment,all rats were sacrificed and the left maxillary were harvested.The alveolar bone loss was observed and measured with stereoscopic microscope.RESULTS Except of the dental plaque index,the clinical indicators in Yunnan Baiyao group were decreased in comparison with those in model group.In Yunnan Baiyao group,the distance of CEJ -ABC was significantly lower than that in model group.CONCLUSION Yunnan Baiyao can improve oral clinical indicators and relieve the symptoms of experimental periodontitis.
作者 黎慧 于浩滢 杨小佳 杜俊蓉 LI Hui;YU Haoying;YANG Xiaojia;DU Junrong(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041P.R.China)
出处 《华西药学杂志》 CAS CSCD 2018年第6期582-584,共3页 West China Journal of Pharmaceutical Sciences
关键词 云南白药 牙周炎模型 骨吸收 菌斑指数 牙龈指数 探诊深度 附着丧失 龈沟出血指数 Yunnan Baiyao Periodontitis model Alveolar bone loss Plaque index Gingival index Probing depth Attachment loos Sulcular bleeding index
作者简介 黎慧,正攻读药理学专业的硕士学位。Email:Echo_lee21@163.com;通信作者:杜俊蓉(Correspondent author),Email:dujr_l@163.com
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