OBJECTIVE To study the therapeutic effect of Yunnan Baiyao extracts on experimental periodontitis in rats.METHODS Healthy SD rats'left maxillary second molar (M2)were ligated with orthodontic steel wire and fed with 10%high sugar water daily to induce rat periodontitis model,and the successful models were picked and randomly divided into model group and Yunnan Baiyao group.Another 7rats were not given any treatment as the blank control group.The clinical indicators were measured every 2weeks. After 5weeks of treatment,all rats were sacrificed and the left maxillary were harvested.The alveolar bone loss was observed and measured with stereoscopic microscope.RESULTS Except of the dental plaque index,the clinical indicators in Yunnan Baiyao group were decreased in comparison with those in model group.In Yunnan Baiyao group,the distance of CEJ -ABC was significantly lower than that in model group.CONCLUSION Yunnan Baiyao can improve oral clinical indicators and relieve the symptoms of experimental periodontitis.
West China Journal of Pharmaceutical Sciences
Alveolar bone loss
Sulcular bleeding index