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文拉法辛与呋喃唑酮治疗有害饮酒的比较 被引量:5

Venlafaxine vs furazolidone in treating harmful alcoholics
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摘要 目的:比较文拉法辛与呋喃唑酮对有害饮酒治疗的疗效、不良反应以及治疗过程中的心境变化。方法:有害饮酒者共68例均为男性,分为2组。文拉法辛组34例,年龄37 a± s 6 a,给文拉法辛25~50 mg,po,tid。呋喃唑酮组34例,年龄38 a±6 a,给呋喃唑酮0.1~0.2 g,po,tid,在服用呋喃唑酮期间,间断饮用白酒。结果:文拉法辛组,3 mo戒断总有效率79%,治疗过程中不良反应不明显,焦虑、抑郁分数较低。呋喃唑酮组戒断治疗总有效率65%,与文拉法辛组相比差异有显著意义(P<0.05)。治疗过程中出现血压变化、心肌缺血等药物不良反应较重,治疗后的焦虑、抑郁分数较高。结论:文拉法辛治疗有害饮酒不良反应少于呋喃唑酮,治疗有效率高于呋喃唑酮。 AIM: To compare the effects, adverse reactions and emotion change of venlafaxine vs furazolidone for harmful alcoholics. METHODS: Sixty eight patients with harmful alcoholics were divided into two groups. Thirty four patients (M34; age 37 a± s 6 a) were treated with venlafaxine, 25-50 mg, po, tid, for 8 wk. The other thirty four patients (M34;age 38 a±6 a) with furzolidone, 0.1-0.2 g, po, tid, for 8 wk, with drinking alcohol at regular intervals during treating with furazolidone. RESULTS: The total effective rate was 79% in venlafaxine group at 3 mo. There were no obvious adverse reactions, the anxiety disorder and depressive disorder during treating with venlafaxine. And the total effective rate was 65% in furazolidone group ( P <0.05). There were obvious adverse reactions such as hypotension, myocardial ischemia, anxiety disorder and depressive disorder after treating with furazolidone. CONCLUSION: Adverse reaction of venlafaxine on harmful alcoholics is smaller than furazolidone and the effect of venlafaxine on alcoholics is better than furazolidone.
作者 张丽 全成实 庞治兴 朴贞素 ZHANG Li 1, QUAN Cheng Shi 1, PANG Zhi Xing , PIAO Zhen Su 2 (1. First clinical college, Norman Bethune University of Medical Sciences, Changchun JILIN 130021, China; 2. Mental Health Hospital, Norman Bethune University of Medical Sciences, Changc
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2001年第2期 111-114,共4页 Chinese Journal of New Drugs and Clinical Remedies
关键词 文拉法辛 呋喃唑酮 戒酒药 饮酒 酒精中毒 venlafaxine furazolidone alchol determents alcohol drinking alcoholism
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