目的：比较文拉法辛与呋喃唑酮对有害饮酒治疗的疗效、不良反应以及治疗过程中的心境变化。方法：有害饮酒者共68例均为男性，分为2组。文拉法辛组34例，年龄37 a± s 6 a,给文拉法辛25～50 mg,po,tid。呋喃唑酮组34例，年龄38 a±6 a，给呋喃唑酮0.1～0.2 g,po,tid,在服用呋喃唑酮期间，间断饮用白酒。结果：文拉法辛组，3 mo戒断总有效率79%，治疗过程中不良反应不明显，焦虑、抑郁分数较低。呋喃唑酮组戒断治疗总有效率65%，与文拉法辛组相比差异有显著意义(P<0.05)。治疗过程中出现血压变化、心肌缺血等药物不良反应较重，治疗后的焦虑、抑郁分数较高。结论：文拉法辛治疗有害饮酒不良反应少于呋喃唑酮，治疗有效率高于呋喃唑酮。
AIM: To compare the effects, adverse reactions and emotion change of venlafaxine vs furazolidone for harmful alcoholics. METHODS: Sixty eight patients with harmful alcoholics were divided into two groups. Thirty four patients (M34; age 37 a± s 6 a) were treated with venlafaxine, 25-50 mg, po, tid, for 8 wk. The other thirty four patients (M34;age 38 a±6 a) with furzolidone, 0.1-0.2 g, po, tid, for 8 wk, with drinking alcohol at regular intervals during treating with furazolidone. RESULTS: The total effective rate was 79% in venlafaxine group at 3 mo. There were no obvious adverse reactions, the anxiety disorder and depressive disorder during treating with venlafaxine. And the total effective rate was 65% in furazolidone group ( P <0.05). There were obvious adverse reactions such as hypotension, myocardial ischemia, anxiety disorder and depressive disorder after treating with furazolidone. CONCLUSION: Adverse reaction of venlafaxine on harmful alcoholics is smaller than furazolidone and the effect of venlafaxine on alcoholics is better than furazolidone.
Chinese Journal of New Drugs and Clinical Remedies