Objective： To study the efficacy of short-term gonadotropin-releasing hormone agonist （GnRH-a） treatment after la- paroscopic conservative surgery in Ovarian Endometriosis-associated infertility patients. Methods： The clinical data of 126 infertile pa- tients with ovarian endometriosis who received surgical therapy in the hospital from May 2008 to May 2011 were analyzed retrospectively, treatment group were treated with intravenous injection of GnRH-a for three courses after surgery, control group were encouraged to get pregnancy, the symptom relief rate and conception conditions in these two groups were observed. Results： The symptom relief rate in treatment group was higher than in control group, and the difference was statistically significant （P〈0.05）; Total pregnancy rate in treat- ment group was higher than in control group, but there was no significant difference （P〉0.05）; There was no significant difference （P〉0. 05） in abortion rate between two groups; The pregnancy rate was highest in the first year treatment in two groups with no statistically sig- nificant difference （P〉0.05）; Compared with control group, the cumulative pregnancy rate of treatment group was higher during fol- low-up （P〉0.05）; Pregnancy rate in stage Ⅰ - Ⅱ and Ⅲ-Ⅳ patients of two groups were more than 50% （P〉0.05）. Conclusion： This study further clarify laparoscopic surgery combined with GnRH-a treatment to ovarian endometriosis infertility patients can better improve their symptoms and pregnancy rates, but no difference in pregnancy rates with expectant treatment. Most of the pregnancy occurred in the first year after surgery or combined with GnRH-a therapy, considering the actual situation, other assisted reproductive methods such as assist- ed reproductive technology should be early encouraged for those patients remaining infertile for over one year after treatment, to increase the chances of conceiving.
Progress in Modern Biomedicine
Gonadotropin-releasing hormone agonist