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重度子痫前期患者血清可溶性CD40L的表达水平与意义 预览 被引量:2

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摘要 目的观察重度子痫前期(SPE)患者血清可溶性CD40L(sCD40L)的表达水平,并探讨其意义。方法60例sPE按孕周分为早发型(孕周〈34周)和晚发型(孕周/〉34周)各30例,分别选择同期健康孕妇各30例作为对照1组、2组。用ELISA法检测研究对象血清sCD40L,用免疫散射比浊法检测血清CRP;用ROC曲线对血清sCD40L和CRP诊断sPE的性能进行评价。结果早发型SPE组血清sCD40L和c反应蛋白(CRP)水平均高于对照1组(t分别为13.79、4.77,P均〈0.01),晚发型sPE组血清sCD40L和CRP水平均高于对照2组(t分别为5.19、3.80,P均〈0.01),早发型和晚发型sPE组血清sCD40L差异有统计学意义(t=6.97,P〈0.01);早发型、晚发型sPE组血清sCD40L水平分别与其CRP水平呈正相关(r分别为0.615、0.568,P均〈0.01);sCIMOL诊断sPE的ROC曲线下面积(AUC ROC)0.926大于CRP的0.785;当sCD40L的cutoff值为4.58ng/mL时,诊断sPE的敏感性为86.7%,特异性为85.O%,Youden指数为0.717;当CRP的cutoff值为2.85mg/L时,诊断sPE的敏感性为80.0%,特异性为66.7%,Youden指数为0.467。结论sPE患者血清中sCD40L呈高水平,对辅助诊断sPE有一定价值。
出处 《临床检验杂志》 CAS CSCD 北大核心 2014年第3期204-206,共3页 Chinese Journal of Clinical Laboratory Science
作者简介 周进福,1981年生,男,主管技师,硕士研究生,研究方向为新生儿疾病筛查和免疫性疾病。 通信作者:沈晓丽,教授,硕士研究生导师,E—mail:sxli3318@163.com。
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