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五丹散凝胶治疗糖尿病并牙周炎免疫调节机制探讨 被引量:7

Immunoregulatory Mechanism of Wudan San Gel in Diabetic Patients Complicated with Periodontitis
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摘要 【目的1探讨五丹散凝胶治疗糖尿病并牙周炎的免疫调节作用机制。【方法】将100例糖尿病并牙周炎患者随机分为2组.对照组给予牙周基础治疗.试验组加用五丹散凝胶治疗,7d为1个疗程,连续治疗3个疗程,观察治疗前后2组患者牙周指标和白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的变化情况。【结果】(1)治疗后2组的IL-6水平下降,IL-4、IL-10水平升高,与治疗前比较,差异有统计学意义(P〈0.05);治疗后组间比较,差异均有统计学意义(P〈0.05)。(2)菌斑指数(PLI)、探诊出血(BOP)及牙齿松动指数(TM)与血清IL-4呈负相关(OR=0.934,0.972,0.976),PLI、BOP、牙龈指数(GI)及TM与IL-6呈正相关(OR=1.022,1.054,1.048,1.060),BOP、GI及探诊深度(PD)与IL-10呈负相关(OR=0.952,0.976,0.984)。【结论】五丹散凝胶通过降低血清IL-6含量,提高IL-4及IL-10含量.调整体内Th1/Th2细胞因子平衡.对糖尿病并牙周炎患者的牙周治疗有良好的效果。 Objective To investigate the effects of Wudan San Gel on the serum levels of interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-10 (IL-10) in diabetes mellitus (DM) patients complicated with periodontitis, and to explore its immunoregulatory therapeutic mechanism in treating periodontitis. Methods This study consisted of 100 DM patients complicated with periodontitis, which were evenly randomized to experiment group and control group. Patients in the control group received periodental non-surgical treatment, and those in the experiment group received Wudan San Gel. Seven days constituted one treatment course and the whole treatment lasted for 3 courses. The changes of periodontal indexes such as plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing depth (PD) and tooth mobility (TM), and the serum levels of IL-4, IL-6 and IL-10 were observed. Results (1) After treatment, serum IL-6 level was decreased, and IL-4 and IL-10 levels were increased (P〈0.05 compared with those before treatment), and the differences were significant between the two groups (P〈0.05). (2)PLI, BOP and TM were negatively correlated with IL-4 level [odd ratio (OR) being 0.934, 0.972, 0.976, respectively), PLI, BOP, GI and TM were positively correlated with IL-6 (OR being 1.022, 1.054, 1.048, 1.060, respectively), and BOP, GI and PD were negatively correlated with IL-10 (OR being 0.952, 0.976, 0.984, respectively). Conclusion Wudan San Gel shows satisfactory therapeutic effect for DM patients complicated with periodontitis through decreasing IL-6, increasing IL-4 and IL-10, and regulating the balance of cytokines of Th1/Th2.
作者 李建文 崔丽娟 钟瑾 LI Jianwen, CUI Lijuan, ZHONG Jin (The First People's Hospital of Baiyun District, Guangzhou 510400 Guangdong, China)
出处 《广州中医药大学学报》 CAS 北大核心 2013年第6期828-831,835共5页 Journal of Guangzhou University of Traditional Chinese Medicine
基金 广州市白云区科技计划项目(编号:2011-KZ-15)
关键词 糖尿病 牙周炎 中药疗法 五丹散凝胶 治疗应用 白细胞介素-4 白细胞介素-6 白细胞介素-10 Diabetes Mellitus Periodontitis/TCD therapy Wudan San Gel/therapeutic use Interleukin-4 Interleukin-6 Interleukin-10
作者简介 李建文(1966-),男,主治医师;E—mail:13802751052@139.com 通讯作者:崔丽娟,硕士研究生,主任医师;E-mail:cui-lijuan@163.com
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