Objective： To investigate the effect of L. plantarum LIP-1 on blood lipid-lowering and antioxidant activity in the hyperlipidemia rats. Method：24 Wistar male rats were divided into three groups：control group, model group and test group. The control group was fed normal diet. The model and test groups were fed high fat diet. The control group was given 0.9% NaCl while the test and model group were given viable cells of L. plantarum LIP-1 and skim milk for 28 d, respectively. Then the serum lipids, anti-oxidation activity of serum and liver, liver and fecal cholesterol, fecal total bile acids and short-chain fatty acids were measured. Results： The serum level of TC, TG, LDL-C and MDA in the test group were significantly lower（P〈0.05） than those in model group and the serum level of HDL-C and the activi- ty of GSH-Px were significantly higher （P〈0.05） than those in model group. The activity of GSH-Px in liver tissue ho- mogenate significantly higher （P〈0.05） than those in model group and MDA in liver tissue homogenate significantly lower （P〈0.05） than those in model group. The test group had a significant reduction in liver cholesterol content （P〈0.05） and an increase in fecal cholesterol content compared to the model group （P〈0.05）. Fecal short-chain fatty acids was signifi- cantly higher in rats fed L. plantarum LIP-1 than the model group（P〈0.05）. Conclusion： L. plantarum LIP-1 has a pos- itive effect on the blood lipid in the hyperlipidemia rats. A s~gnificant relationship was noted between the hycholes- terolemic effect of L. plantarum LIP-1 and its anti-oxidation activity. The mechanisms behind the hypocholesterolemic effect of L. plantarum LIP-1 is likely to be diverse and will need further investigations.
Journal of Chinese Institute Of Food Science and TEchnology