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植物乳杆菌LIP-1对高脂血症大鼠血脂的调节作用 被引量:13

Effects of L. Plantarum LIP-1 on Blood Lipids Regulation in Hyperlipidemia Rats
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摘要 目的:探讨植物乳杆菌LIP-1的降血脂作用及其机理。方法:将24只雄性Wistar大鼠按体重分为正常对照组、高脂模型组及实验组,其中后两组给予高脂饲料喂养,并每日给上述3组分别灌胃0.9%生理盐水、脱脂乳和活菌制剂,28d后测定相关指标。结果:实验组血清总胆固醇、低密度脂蛋白胆固醇、甘油三酯和丙二醛含量明显低于高脂模型组(P〈0.05),而血清高密度脂蛋白胆固醇含量和血清的谷胱甘肽过氧化物活力明显高于高脂模型组(P〈0.05);肝脏组织匀浆中的谷胱甘肽过氧化物酶活力明显高于高脂模型组(P〈0.05),丙二醛含量明显低于高脂模型组(P〈0.05),肝脏中的胆固醇含量明显低于高脂模型组(P〈0.05),粪便中的胆固醇及短链脂肪酸含量明显高于高脂模型组(P〈0.05)。结论:植物乳杆菌LIP-1对高脂血症大鼠有明显的降血脂作用,其作用机理涉及抗氧化作用在内的多种途径。 Objective: To investigate the effect of L. plantarum LIP-1 on blood lipid-lowering and antioxidant activity in the hyperlipidemia rats. Method:24 Wistar male rats were divided into three groups:control group, model group and test group. The control group was fed normal diet. The model and test groups were fed high fat diet. The control group was given 0.9% NaCl while the test and model group were given viable cells of L. plantarum LIP-1 and skim milk for 28 d, respectively. Then the serum lipids, anti-oxidation activity of serum and liver, liver and fecal cholesterol, fecal total bile acids and short-chain fatty acids were measured. Results: The serum level of TC, TG, LDL-C and MDA in the test group were significantly lower(P〈0.05) than those in model group and the serum level of HDL-C and the activi- ty of GSH-Px were significantly higher (P〈0.05) than those in model group. The activity of GSH-Px in liver tissue ho- mogenate significantly higher (P〈0.05) than those in model group and MDA in liver tissue homogenate significantly lower (P〈0.05) than those in model group. The test group had a significant reduction in liver cholesterol content (P〈0.05) and an increase in fecal cholesterol content compared to the model group (P〈0.05). Fecal short-chain fatty acids was signifi- cantly higher in rats fed L. plantarum LIP-1 than the model group(P〈0.05). Conclusion: L. plantarum LIP-1 has a pos- itive effect on the blood lipid in the hyperlipidemia rats. A s~gnificant relationship was noted between the hycholes- terolemic effect of L. plantarum LIP-1 and its anti-oxidation activity. The mechanisms behind the hypocholesterolemic effect of L. plantarum LIP-1 is likely to be diverse and will need further investigations.
作者 王俊国 孟和毕力格 包秋华 丹彤 张和平 Wang Junguo Menghe Bilige Bao Qiuhua Dan Tong Zhang Heping (Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education PRC; College of Food Science and Engineering, Inner Mongolia Agricultural University, Huhhot 010018)
出处 《中国食品学报》 EI CAS CSCD 北大核心 2013年第2期6-12,共7页 Journal of Chinese Institute Of Food Science and TEchnology
基金 国家自然科学基金项目(30840011,31160315) 内蒙古自然科学基金项目(200508010406) 内蒙古自然基金开放课题(20102010)
关键词 植物乳杆菌LIP-1 高脂血症大鼠 降血脂作用 抗氧化能力 L. plantarum LIP-l hyperlipidemia rat blood lipid-lowering anti-oxidation
作者简介 王俊国,男,1970年出生,博士,副教授 通讯作者:张和平
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  • 1Deaton C., Froelicher E.S., Wu L.H., et al. The global burden of cardiovascular disease[J]. J Cardiovasc Nurs, 2011, 26(4) : 5-14. 被引量:1
  • 2Le Blanc J.G., Garro M. S., Silvestroni A, et al. Reduction of alpha-galactooligosaccharides in soyamilk by Lacto- bacillus fermentum CRL 722: in vitro and in vivo evaluation of fermented soymilk[J]. Appl Microbiol, 2004, 97(4): 876-881. 被引量:1
  • 3Man G. V., Spoerry A. Study of surfactant and cholesteremia in the Maasai[J]. Am J Clin Nutri, 1974, 27: 464- 469. 被引量:1
  • 4Nguyen T.D.T., Kang J.H., Lee M.S. Characterization of Lactobacillus plantarum PH04, a potential probiotic bac- terium with cholesterol-lowering effects[J]. Int J Food Microbiol, 2007, 113: 358-361. 被引量:1
  • 5Jeun J., Kim S.Y., Cho S.Y., et al. Hypocholesterolemic effects of LactobaciUus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice[J]. Nutrition, 2010, 26: 321-330. 被引量:1
  • 6Lye H.S., Rusul G., Liong M.T. Mechanisms of cholesterol removal by lactobacilli under conditions that mimic the human gastrointestinal tract[J]. Int Dairy J, 2010, 20:169-175. 被引量:1
  • 7Ooi L. G., Liong M. T. Cholesterol-lowering effects of probiotics and prebiotics: A review of in vivo and in vitro findings[J]. Int J Mol Sci, 2010, 11: 2499-2522. 被引量:1
  • 8内村泰 冈田早苗.乳酸菌实验手册(日文版)[M].朝仓书店,1992.. 被引量:7
  • 9Folch J., Lees M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipids from an- imal tissues[J]. J Biol Chem, 1957, 226: 497-509. 被引量:1
  • 10Tabuchi M., Tamura A., Yamada N., et al. Hypocholesterolemic effects of viable and heat-sterilized cells of Lacto- bacillus GG in rats fed a high-cholesterol diet[J]. Milchwissenschaft, 2004, 59: 249-253. 被引量:1

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