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子宫内膜异位症发病相关因素的临床研究 被引量:90

Clinical study of the related risk factors associated with endometriosis
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摘要 目的研究不同年龄阶段子宫内膜异位症的发病率,并探讨子宫内膜异位症发病的相关因素。方法采用病例一对照研究,收集346例子宫内膜异位症患者(研究组)和346例非子宫内膜异位症患者(对照组)的相关资料(包括年龄、个体因素、月经状况和生殖活动等),采用单因素和多因素非条件Logistic回归进行分析。结果①子宫内膜异位症发病年龄高峰为25~50岁。②单因素分析结果显示,子宫内膜异位症发病的危险因素有:干部和技术人员,大学以上学历;A型和。型血;初潮年龄≤13岁;月经周期〈27d,经期≥8d;痛经;足月产1次;人工流产次数≥2次;不孕;放置宫内节育器(IUD)避孕。两组比较差异均有统计学意义(P〈0.05)。③多因素分析结果显示,初潮年龄早、月经周期短、经期长、人工流产次数多是子宫内膜异位症的危险因素;孕次增多、产次增多使发生子宫内膜异位症的危险性减少,是子宫内膜异位症的保护因素。结论子宫内膜异位症发病与初潮年龄早、月经周期短、经期长、人工流产次数多有关。 Objective To investigate the hospital-base incidence of endometriosis among women with different ages and the risk factors associated with endometriosis. Methods A case control study was carded out in Jinan including 346 endometriosis patients and 346 healthy people. The data were collected and analyzed with single factor analysis and mul- tivariate unconditional logistic regression analysis among age, individual aspects, menstrual characteristics and reproductive activity. Results (1) The age peak of incidence of endometriosis was between 25 and 50. (2) Single factor analysis showed that occupation as cadre and mechanics, college educated, A and O blood types, menarche before or just at age 13, menstrual cycle 〈 27 days, menstruallengths 〉 or = 8 days, dysmenorrhea, one live birth, abortion numbers 〉 or = 2, infertility and intrauterine device use were identified as risk factors. There were significant differences between the two groups(P 〈 0.05). (3) Multifactor analysis confirmed that the risk factors associated with endometriosis included early menarche, short cycles, long menstrual lengths and more abortions numbers. Pregnancy number and labor number were proved to be the protective factors. Conclusion Endometriosis seemed to be related to early menarche, short cycles, long menstrual lengths, and more abortions numbers.
作者 于玲 田永杰 YU Ling, TIAN Yong-jie ( Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China)
出处 《山东大学学报:医学版》 CAS 北大核心 2013年第2期79-83,共5页 Journal of Shandong University:Health Sciences
关键词 子宫内膜异位症 危险因素 病例对照研究 LOGISTIC回归 Endometriosis Risk factor Case control study Logistic regression
作者简介 于玲(1973-),女,硕士,主治医师,主要从事妇科肿瘤的研究。E-man:lxy@sdco.gov.cn 通讯作者:田永杰(1964-),男,博士,教授,主任医师,博士生导师,主要从事普通妇科和妇科肿瘤的研究。E—mail:tianyongjie@stu.edu.cn
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