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脑梗死患者sCD40L与CRP含量的改变及其临床意义 被引量:1

Changes of sCD40L and CRP in patients with cerebral infarction and its clinical significance
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摘要 目的探讨sCD40L和CRP的含量与动脉粥样硬化性脑梗死(Atherosclerotic cerebral infarc-tion,ACI)面积、NIHSS量表评分之间的相关性。方法采用双抗体夹心酶联免疫法及比浊法检测63例ACI患者及30例体检健康者的血清sCD40L和CRP含量,采用SPSS16.0软件进行统计学分析。结果 ACI患者血清sCD40L和CRP含量显著高于正常对照组,且病情越重及脑梗死面积越大的患者,血清sCD40L和CRP含量就越高,入院即时和入院14 d血清sCD40L与CRP含量呈正相关,通过绘制ROC曲线得出,sCD40L曲线下面积(0.954)大于CRP曲线下面积(0.869),sCD40L特异度(100%)高于CRP(96.7%),sCD40L灵敏度(84.1%)也高于CRP(69.8%)。结论 sCD40L、CRP含量的改变可作为判断ACI病情的血清生物学指标。 Objective To investigate the correlation between the content of sCD40L and CRP and atherosclerotic cerebral infarction area,NIHSS scale score.Methods Serum sCD40L and CRP levels of 63 ACI patients and 30 healthy persons were tested by double antibody sandwich enzyme immunoassay and turbidimetric assay,SPSS 16 software was used for statistical analysis.Results ACI patients with serum sCD40L and CRP contents were significantly higher than in normal controls,and more advanced disease and cerebral infarction area more patients,the serum sCD40L and CRP content is higher,the instant and the 14 day of admission admission serum sCD40L and CRP levels were positively associated,by plotting ROC curves,the area under the sCD40L curve(0.954) is greater than CRP curve area(0.869),sCD40L specificity(100%) was higher than that of CRP(96.7%),sCD40L sensitivity(84.1%) over CRP(69.8%).Conclusions SCD40L,CRP content change can be used to judge the ACI disease serum biological markers.
作者 凌启节 储照虎 Lin Qijie,Chu Zhaohu.Department of Neurology,Chi zhou people's Hospital,Chizhou 247000
出处 《卒中与神经疾病》 2012年第2期 91-96,共6页 Stroke and Nervous Diseases
关键词 动脉粥样硬化性脑梗死 可溶性CD40L C-反应蛋白 Atherosclerotic cerebral infarction Soluble CD40L C-reactive protein
作者简介 储照虎(通讯作者)
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参考文献20

  • 1Tabara N,Imaizumi T,Yirmani R,et al.Clinical feasibility of mo-lecular imaging of plaque inflammation in athemsclerosis.J NuclMed,2009,50(3):331-334. 被引量:1
  • 2Santilli F,Basilis,Feffonip,et al.CD40/CD40L system and vascu-lar disease.Intern Emerg Med,2007,2(4):256-258. 被引量:1
  • 3Charalambos Antoniades,MD,Constantinos Bakogiannis,MD,Dimitris Tousoulis,MD,et al.The CD40/CD40 Ligand SystemLinking Inflammation With Atherothrombosis.Journal of the A-merican College of Cardiology.2009,54(8):670. 被引量:1
  • 4Jin Y,Nonoyama S,Morio T,et al.Characterization of solubleCD40 ligand released from human activated platelets.Med DentSci,2001,48(1):23-27. 被引量:1
  • 5高路,南佳彦,姜保周,许寒炬.急性脑梗死患者24h内超敏-C反应蛋白水平及相关研究[J].中华急诊医学杂志,2004,13(3):175-177. 被引量:60
  • 6Charkrabartl S,Blair P,Freedman JE.CD40-CD40L signaling invascular inflammation.J Biol chem,2007,282(25):18307-18317. 被引量:1
  • 7Yuan M,Ohishi M,Wang L,et al.Association between serumlevels of soluble CD40/CD40 ligand and organ damage in hyper-tensive patients.Clin Exp Pharmacol Physiol,2010,23(4):344-353. 被引量:1
  • 8Plaikner M,Peer A,Falkensammer G,et al.Lack of associationof soluble CD40 ligand with the presence of acute myocardial in-farction or ischemic stroke in the emergency department.ClinChem,2009,55(7):175-178. 被引量:1
  • 9Missiou A,Wolf D,Platzer I,Ernst S,Walter C,Rudolf P,et al.CD40L induces inflammation and adipogenesis in adipose cells apotential link between metabolic and cardiovascular disease.Thromb Haemost,2010,103(2):985-988. 被引量:1
  • 10Ferro D,Loffredo L,Polimeni L,et al.Soluble CD40ligand pre-dicts ischemic stroke and myocardial infarction in patients withnonvalvular atrial fibrillation.Arterioscler Thromb Vasc Biol,2007,27(12):2763-2768. 被引量:1

二级参考文献10

  • 1Takahashi H, lwanaga Y, Aoyama T, et al. High - sensitive C - creative Protein (CRP) assay - a novel method for assessment of risk rations for atherosclerotic vascular disease. Jap J Clinical Pathology, 2002, 50 :30 - 39. 被引量:1
  • 2Kaplan M, Zebrak J. Usefulness of high - sensitivity C - creative protein in predicting long - term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. The American Journal of Ca 被引量:1
  • 3Paul M. A new test for heart attack and stroke risk. N Engl J Med, 2000272:62-63. 被引量:1
  • 4Burke P, Tracy, Kolodgie, et al. Elevated c - reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. 2002 American Heart Association, 105: 2019 - 2023. 被引量:1
  • 5Thienel U,Loike J,Yellin MJ,et al.CD154(CD40L)induces Hu-man endothelial cell chemokine production and migration of Leuko-cyte subsets[].Cellular Immunology.1999 被引量:1
  • 6Mach F,Schonbeck U,Sukhova G K,et al.Functional CD40Ligand is expressed on human vascular endothelial cells,smooth Muscle cells,and macrophages:implications for CD402CD40Ligand signa-ling in atherosclerosis[].Proceedings of the National Academy of Sciences of the United States of America.1997 被引量:1
  • 7Ross R.Athensclerosis-an inflammation disease[].The New England Journal of Medicine.1999 被引量:1
  • 8Bruemmer D,Riggers U,HolzmeisterJ,et al.Expression of CD40in-vascular smooth musclec ells and macrophagesis Associated with ear-ly development of human atherosclerotic lesions[].The American Journal of Cardiology.2001 被引量:1
  • 9徐耕,金国栋,傅国胜,马骥,施育平,单江.急性冠状动脉综合征患者C—反应蛋白及其1059G/C基因多态性的研究[J].中华急诊医学杂志,2003,12(4):223-226. 被引量:39
  • 10高路,李旭东,南佳彦,徐秀丽.短暂性脑缺血发作患者血清高敏—C反应蛋白的水平变化与脑血栓形成的关系[J].中国急救医学,2003,23(7):466-468. 被引量:24

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