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角化性皮肤病和炎症性皮肤病与屏障功能异常的关系

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摘要 角质层屏障由角质形成细胞(KC)和细胞间脂质构成,二者形成“砖-水泥”样的结构,即亲水的、富含纤维蛋白的KC(砖)被疏水的脂质双分子层状结构(水泥)所包绕。这种结构可以防止皮肤内的水分和电解质丢失,还可以抵御外界理化因素进入对皮肤的损伤。角质层在阻挡微生物入侵的同时,还有许多表皮抗菌肽可以使正常菌群繁殖的同时抑制致病微生物的生长。
出处 《国际皮肤性病学杂志》 2011年第1期56-58,共3页 International Journal of Dermatology and Venereology
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参考文献18

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