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乳酸菌胆盐水解酶生理特性和分子生物学的研究进展 预览 被引量:1

Research Progress in Physiological Characteristics and Gene Sequencing of Bile Salt Hydrolase from Lactic Acid Bacteria
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摘要 一些乳酸菌及其相关制品含有胆盐水解酶,具有降低介质以及血清中胆固醇含量的能力。胆盐水解酶使结合态胆酸的类固醇中心基团与氨基酸基团之间酰基键断裂,释放脱结合态胆酸。肠道中脱结合态胆盐比结合态胆盐溶解度小,不易被人体吸收,导致大量脱结合态胆盐被分泌到粪便中排出体外。该文章围绕近年来乳酸菌中胆盐水解酶的一些研究进展,综述了胆盐水解酶的特性和分子生物学信息。 Bile salt hydrolase is an enzyme found in in vivo or in vitro investigations on some lactic acid bacteria and also found in relevant products,and has the ability to reduce cholesterol in media and serum.The enzyme breaks the acyl bond between the amino acid group and the central group in steroid to release deconjugated bile acid.Solubility of deconjugated bile salts is lower than that of conjugated bile salts so that the deconjugated bile salts are hard to be absorbed in the intestinal tract and are the secreted in feces.Physiological characteristics and molecular biological information of bile salt hydrolase are reviewed in this paper,which will provide a reference for future studies.
作者 张红星 王廿 刘勇 刘丽 滕国新 刘慧 ZHANG Hong-xing,WANG Nian,LIU Yong,LIU Li,TENG Guo-xin,LIU Hui(1.Department of Food Science,Beijing University of Agriculture,Beijing 102206,China;2.College of Biological Engineering,Henan University of Technology,Zhengzhou 450001,China;3.Beijing Sanyuan Foods Co.Ltd.,Beijing 100085,China)
出处 《食品科学》 CAS CSCD 北大核心 2011年第1期302-305,共4页 Food Science
基金 北京市科委自主知识产权与技术标准试点专项资金项目(Z0706002) 北京市自然科学基金项目(5092008) 北京市重点建设学科项目(PXM2009_014207_078172)
关键词 乳酸菌 胆盐水解酶 胆固醇 lactic acid bacteria bile salt hydrolase cholesterol
作者简介 张红星(1970-),男,副教授,博士,研究方向为采后生物技术和食品生物安全。E—mail:hxzhang511@sohu.com 通信作者:刘慧(1963-),女,副教授,研究方向为食品微生物和功能食品。E-mail:foodlh@263.net
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