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小蜡树的酚苷及苯乙醇苷类成分 被引量:11

Phenolic and phenylethanoidal glycosides from branch of Fraxinus sieboldiana
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摘要 目的:系统研究小蜡树Fraxinuxsieboldiana枝乙醇提取物的化学成分。方法:运用正相和反相硅胶、大孔吸附树脂、凝胶、反相高效液相等色谱方法进行分离;应用包括一维和二维NMR等波谱方法鉴定化合物的结构。结果:从小蜡树枝的乙醇提取物水相部位分离得到4个酚苷和12个苯乙醇苷类成分,分别鉴定为:2,6-二甲氧基-对苯二酚-4-O-β-D-吡喃葡萄糖苷(1),2,6-二甲氧基-对苯二酚-1-O-β-D-吡喃葡萄糖苷(2),4-羟基-3-甲氧基苯基β-D-吡喃葡萄糖苷(3),4-羟基-3-甲氧基苯基β-D-吡喃木糖基(1→6)-O-β-D-吡喃葡萄糖苷(4),osmanthuside H(5),2-(4-羟基苯基)乙基β-D-吡喃葡萄糖苷(6),2-(3,4-二羟基苯基)乙基β-D-吡喃葡萄糖苷(7),2-羟基-4-(2-羟基乙基)-苯基β-D-吡喃葡萄糖苷(8),4-(2-羟基乙基)-2-甲氧基苯基β-D-吡喃葡萄糖苷(9),calceolarioside B(10),calceolarioside A(11),ferruginoside A(12),isolugrandoside(13),类叶升麻苷(14),chiritotoside C(15)和plantasisoside(16)。结论:化合物1-4,9,12,13和16为首次从该属植物中分离得到。 Objective:To investigate chemical constituents from an ethanolic extract of the branch of Fraxinus sieboldiana(Oleaceaue).Method:The constituents were isolated and purified by a combination of various chromatographic techniques including silica gel,macroporous adsorbent resin,Sephadex LH-20,and preparative HPLC.Structures of the isolates were elucidated by spectroscopic methods including 1D and 2D NMR and MS techniques.Result:Four phenolic and twelve phenylethanoidal glycosides were obtained and their structures were identified as 2,6-dimethoxy-p-hydroquinone-4-O-β-D-glucopyranoside(1),2,6-dimethoxy-p-hydroquinone-1-O-β-D-glucopyranoside(2),4-hydroxy-3-methoxyphenyl β-D-glucopyranoside(3),4-hydroxy-3-methoxyphenyl β-D-xylopyranosyl(1→6)-O-β-D-glucopyranoside(4),osmanthuside H(5),2-(4-hydroxyphenyl) ethyl β-D-glucopyranoside(6),2-(3,4-dihydroxyphenyl) ethyl β-D-glucopyranoside(7),2-hydroxy-4-(2-hydroxyethyl)-phenyl β-D-glucopyranoside(8),4-(2-hydroxyethyl)-2-methoxyphenyl β-D-glucopyranoside(9),calceolarioside B(10),calceolarioside A(11),ferruginoside A(12),isolugrandoside(13),acteoside(14),chiritotoside C(15),and plantasisoside(16).Conclusion: Compounds 1-4,9,12,13 and 16 were obtained from the genus Fraxinus for the first time.
作者 林生 刘明韬 王素娟 李帅 杨永春 石建功 LIN Sheng,LIU Mingtao,WANG Sujuan,LI Shuai,YANG Yongchun,SHI Jiangong (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处 《中国中药杂志》 CAS CSCD 北大核心 2010年第8期992-996,共5页 China Journal of Chinese Materia Medica
基金 长江学者和创新团队发展计划“PCSIRT”(IRT0514) 新世纪优秀人才支持计划(NCET)
关键词 小蜡树 化学成分 酚苷 苯乙醇苷 Fraxinus sieboldiana chemical constituents phenolic glycosides phenylethanoid glycosides
作者简介 [通信作者]石建功,Tel:(010)83154789,Fax:(010)63017757,E—mail:shijg@imm.ac.cn
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参考文献16

  • 1邬家林.梣属植物化学分类与资源利用的研究.川药校刊,1985,(4):18-18. 被引量:3
  • 2Lin S, Wang S J, Liu M T, et al. Glycosides from the stem bark of Fraxinus sieboldiana [ J ]. J Nat Prod, 2007, 70 : 817. 被引量:1
  • 3林生,刘明韬,王素娟,李帅,杨永春,石建功.小蜡树香豆素类成分及其抗氧化活性[J].中国中药杂志,2008,33(14):1708-1710. 被引量:14
  • 4Chung M I, Lai M H, Yen M H, et al. Phenolics from Hypericum geminiflorum[ J ]. Phytochemistry, 1997, 44: 943. 被引量:1
  • 5Otsuka H, Takeuchi M, Inoshiri S, et al. Phenolic compounds from Coix lachrymal- jobi var. Ma-yuen [ J ] . Phytochemistry, 1989, 28(3): 883. 被引量:1
  • 6Kitajima J, Kamoshita A, lshikawa T, et al. Glycosides of Atractylodes japonica[ J]. Chem Pharm Bull, 2003, 51 : 152. 被引量:1
  • 7Sugiyama, M, Kikuchi M. Phenylethanoid glycosides from Osmanthus asiaticus [ J ]. Phytochemistry, 1993, 32 : 1553. 被引量:1
  • 8Tanahashi T, Watanabe H, Itoh A, et al. Five secoiridoid glucosides from Fraxinus formosana [ J ]. Phytochemistry, 1993, 32 : 133. 被引量:1
  • 9Lee T H, Kuo Y C, Wang G J, et al. Five new phenoli'cs from the roots of Ficuz beecheyana[ J]. J Nat Prod, 2002, 65:1497. 被引量:1
  • 10Sugiyama M, kikuchi M. Studies on the constituents of Osmanthus Species. X. Structures of phenolic glucosides from the leaves of Osmanthus asiatius Nakai [ J ]. Chem Pharm Bull, 1992, 40 : 325. 被引量:1

二级参考文献11

  • 1.中国药典:一部[S].,2005.附录10. 被引量:289
  • 2邬家林.梣属植物化学分类与资源利用的研究.川药校刊,1985,(4):18-18. 被引量:3
  • 3Shigetsuna N, Tomio T, Tadanobu I, et al. Pharmacological studies of Fraxinus bark. Ⅻ. Fluorescent substances detected by paper chromatography [ J ]. Iwate Igaku Zasshi, 1968,20:312. 被引量:1
  • 4Tsukamoto H, Hisada S, Nishhibe S. Coumarins from bark of Fraxinus japonica and F. mandshurica var. Japonica[J]. Chem Pharm Bull, 1985,33:4069. 被引量:1
  • 5Kanho H, Yaoya S, Itani T, et al. Glucosylation of phenolic compounds by Pharbitis nil hairy roots : Ⅰ. Glucosylation of coumatin and flavone derivatives [ J ]. Biosci Biotechnol Biochem, 2004,68:2030. 被引量:1
  • 6Ray A B, Chattopadhyay S K, Kumar S, et al. Structure of cleomiscosins, coumarinolignoids of Cleome viscosa seeds [ J ]. Tetrahedron, 1985,41:209. 被引量:1
  • 7Kumar S, Bay A B, Konno C, et al. Cleomiscosin D, a coumarino-lignan from seeds of Cleome vlscosa [ J ]. Phytochemistry, 1988,27(2) :636. 被引量:1
  • 8Yun B S, Lee I K, Kim J P, et al. Curtisians A - D, new free radical scavengers from the mushroom Paxillus curtislii[ J ]. J Antibiotics, 2000,53 : 114. 被引量:1
  • 9刘丽梅,陈琳,王瑞海,吴萍.秦皮化学成分的研究[J].中草药,2001,32(12):1073-1074. 被引量:25
  • 10陈妙华,刘凤山.罗布麻叶镇静化学成分的研究[J].中国中药杂志,1991,16(10):609-611. 被引量:24

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