期刊文献+

支气管哮喘患儿血浆肾上腺髓质素、肿瘤坏死因子-α水平的变化 预览

在线阅读 下载PDF
收藏 分享 导出
摘要 目的观察支气管哮喘(简称哮喘)患儿血浆肾上腺髓质素(AM)、肿瘤坏死因子-α(TNF-α)水平的变化以及与气道阻力值(Rint)、外周血氧分压(PaO2)的关系。方法采用放射免疫分析法,检测30例哮喘急性发作期患儿(发作组)和30例缓解期患儿(缓解组)血浆的AM、TNF-a水平,且与Rint及PaO2进行相关分析。同时以30例健康儿童作为正常对照(对照组)。结果发作组血浆的AM、TNF-α分别为(31.45±6.51)、(1.73±0.49)ng/L,明短高于缓解组的(13.26±4.12)、(1.45±0.43)ng/L及对照组的(11,43±3.52)、(1.21±0.41)ng/L(P〈0.01)。发作组血浆的AM水平与TNF-α水平、Rint呈正相关(r=0.58,P〈0.01;r=0.73,P〈0.01),与PaO2呈负相关(r=0.55,P〈0.01)。结论AM在支气管哮喘的急性发作中起着重要的作用。
作者 饶兴愉 陈强
出处 《江西医学院学报》 CAS 2008年第3期 85-86,88,共3页 Acta Academiae Medicinae Jiangxi
  • 相关文献

参考文献12

  • 1Kitamura K,Kangawa K,Kawamoton M, et al. Adrenomedullin:a Novel Hypotensive Peptide Isolated from Human Pheochromocytoma[J]. Biophys Res Commun, 1993,192 (2) : 553- 560. 被引量:1
  • 2陈育智.儿童支气管哮喘防治常规(试行)[J].中华儿科杂志,2004,42(2):100-106. 被引量:2411
  • 3Nag K, Kato A, Nakada T, et al. Molecular and Functional Characterization of Adrenomedullin Receptors in Pufferfish [J]. Am J Physiol Regul Integr Comp Physiol,2006,290:467- 478. 被引量:1
  • 4Cuesta N, Martinez A, Cuttitta F. et al. Identification of Adrenomedullin in Avian TypeΠ Pneumoeytes:Inereased Expression after Exposure to Air Pollutants[J]. J Histochem Cytochem, 2005,53(6) : 773-780. 被引量:1
  • 5Kohno M, H anchira T, H i rata K, et al. An Accelerated Increase of Plasma Adrenomedullin in Acute Asthma[J]. Metabolism, 1996,45(11) : 1323-1325 被引量:1
  • 6Ohbayashi H, Suito H, Yoshida N, et al. Adrenomedullin Inhibits Ovalbumin-induced Bronchoconstriction and Airway Microvascular Leakage in Guinea-pigs [J]. Eur Respir J, 1999,14: 1076-1081. 被引量:1
  • 7Kamoi H, Kanazawa H, Hirata K,et al. Adrenomedullin Inhibits the Secretion of Cytokine-induced Neurrophil Chemoartractant, a Member of the Interleukin-8 Family, from Rat Alveolar Macrophages[J]. Biochem Biophys Res Commun, 1995,211(3) : 1031-1035. 被引量:1
  • 8吴秀明 ,戴爱国 ,李继红 .肾上腺髓质素及其受体在支气管哮喘发病中对增殖与凋亡的影响[J].中国现代医学杂志,2005,15(8):1271-1274. 被引量:6
  • 9Hofbauer K H,Jensen B L.Krutz A,et al. Tissue Hypoxygenation Activates the Adrenomedullin System in Vivo[J]. Am J Physiol Regul Integr Comp Physiol,2000,278(2):R513. 被引量:1
  • 10林挺岩,刘青.支气管哮喘患者血浆内皮素—1和肿瘤坏死因子含量及其临床意义[J].中华内科杂志,1998,37(3):199-199. 被引量:7

二级参考文献7

  • 1KITAMURA K,KANGAWA K,KAWAMOTO M,et al.Adrenomedullin: a novel hypotensive peptide isolated from human pheochromoc-ytoma [J]. Biochem Biophys Res Commun, 1993,192: 553-560. 被引量:1
  • 2YOSHIHARA F, NISHIKIMI T, OKANO I, et al[J]. Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy[J]. Regul Pep42005, 127(1-3): 239-244. 被引量:1
  • 3ELSASSER TH, KAHL S. Adrenomedullin has multiple roles in disease stress:development and remssion of the inflammatory response[J]. Mierosc Res Tech, 2002, 57: 120-129. 被引量:1
  • 4CHEUNG BM,HWANG IS,LI CY,et al.Increased adrenomedullin expression in lungs in endotoxaemia [J].J Endocrinol, 2004, 181(2): 339-345. 被引量:1
  • 5MATSUI H,SHIMOSAWA T,ITAKURA K,et al.Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia[J]. Circulation, 2004,109(18):2246-2251. 被引量:1
  • 6BARKER S, LEES DM, WOOD EG, et al. Inhhitory effect of adrenomedullin on basal and tumour necrosis factor alpha-stimulated endothelin- 1 sythesis in bovine aortic endothelial cells is independent of cyclic AMP [J].Biochem Phannacol, 2002, 63(2): 149-156. 被引量:1
  • 7SATA.M, KAKOKI M, NAGATA D, et al. Adrenomedullin and nitricoxide inhibit human endothelial cell apoptosis via a cyclic GUP- independent mechanism[J]. Hypertension, 2000,36: 83-88. 被引量:1

共引文献2418

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈