Objective To investigate the pathophysiological role of adrenomedullin （ ADM ） in congenital heart disease. Methods Fifty-nine children with congenital heart disease were studied, who were hospitalized in the Second Hospital of Shandong University from Jan. 2005 to Nov. 2007. The patients were divided into three groups on the basis of hemodynamic indices measured during cardiac catheterization ： high pulmonary blood flow with （ group A ） or without （ group B ） pulmonary hypertension （mean pulmonary arterial pressure 〉 20mmHg, I mmHg = 0. 133 kPa） and a cyanosis group （without high pulmonary blood flow） （ group C）. Six healthy children were used as a control group. Plasma ADM levels were measured by radioimmunoassay. Results The plasma ADM levels from the femoral vein were significantly higher than those from femoral artery in patients with congenital heart disease （ P 〈 0. 05 ）. The patients from group A and group C had higher plasma ADM levels than the controls（ P 〈0. 01 ）. Plasma ADM levels were significantly negatively correlated with mean systemic arterial pressure, oxygen saturation in mixed vein and oxygen saturation in systemic artery but positively corelated with pulmonary vascular resistance. Conclusion Plasma ADM levels are related to pulmonary arterial resistance and hypoxemia. Increased ADM levels may play a role in reducing the pulmonary arterial resistance and alleviating hypoxemia in these patients.
Chinese Journal of Practical Pediatrics
Congenital heart disease
Hypertension of pulmonary