Levofloxacin and ofloxacin were two new oral fluoroquinolones. But the former was the optical s-(-) isomer of ofloxacin. The in vitro antimicrobial activity of levofloxacin was two folder higher than that of ofloxacin. The two drugs were active against most aerobic gram-negative and gram-positive organism and were effective against most infections. Levofloxacin had characterization of broad spectrum, high antimicrobial activity, favourable body fluid and tissue disturbation property, mild adverse drug reaction and few resistance. Because of the modification of its structure, levefloxacin had been proved the same effective and few adverse drug reaction compared with ofloxaction in randomizated controlled clinical trails of lower respiratory tract infection and urinary tract infections with complication when levofloxacin and ofloxacin were administrated simultaneously, but the absorption of levofloxacin and ofloxacin would be decreased when they were administrated with antiacid agents for other divalent, trivalent cation drugs simultaneously.
The Chinese Journal of Clinical Pharmacology