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左旋氧氟沙星和氧氟沙星的临床应用进展与评价 预览 被引量:101

ADVANCES AND EVALUATION OF LEVOFLOXACIN AND OFLOXACIN IN CLINICAL USES
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摘要 左旋氧氟沙星和氧氟水利生是氟喹诺酮类抗菌药,前者是旋光性S-(一)的氧氟沙星异构体。左旋氧氟沙星在体外的抗菌活性天般是氧氟沙星的两倍。两药对大多数需氧性革兰氏阳性菌和寺氏阴性菌都有效,对多种感染有效,具有抗菌谱广、抗菌活性强并有的体液、组织分布性,其不良反应轻、细菌耐药性小等优点,左肇氧氟沙星由于构形的改变,在与氧氟沙星对比的试验中,左旋氧氟沙星按氧氟沙星一半的每日剂量,治疗下呼吸道感和有并发症的 Levofloxacin and ofloxacin were two new oral fluoroquinolones. But the former was the optical s-(-) isomer of ofloxacin. The in vitro antimicrobial activity of levofloxacin was two folder higher than that of ofloxacin. The two drugs were active against most aerobic gram-negative and gram-positive organism and were effective against most infections. Levofloxacin had characterization of broad spectrum, high antimicrobial activity, favourable body fluid and tissue disturbation property, mild adverse drug reaction and few resistance. Because of the modification of its structure, levefloxacin had been proved the same effective and few adverse drug reaction compared with ofloxaction in randomizated controlled clinical trails of lower respiratory tract infection and urinary tract infections with complication when levofloxacin and ofloxacin were administrated simultaneously, but the absorption of levofloxacin and ofloxacin would be decreased when they were administrated with antiacid agents for other divalent, trivalent cation drugs simultaneously.
作者 单爱莲 吕媛 SHAN Ai-Lian, LU Yuan, LI Jia-Tai(The Institute of Clinical Pharmarcology, the First Hospital, Beijing Medical University, Beijing, 100034)
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 1997年第2期 115-119,共5页 The Chinese Journal of Clinical Pharmacology
关键词 左旋氧氟沙星 氧氟沙星 临床应用 levofloxacin ofloxacin
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