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不停跳心内直视手术对心肌细胞凋亡的影响 预览 被引量:4

Influence of Beating Open Heart Operation to Cardiomyocytes Apoptosis
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摘要 【目的】评价不停跳体外循环心内直视手术对心肌细胞凋亡的影响和探讨其临床意义。【方法】停跳心内直视手术患者25例(A组),不停跳心内直视手术患者20例(B组),取心肌组织作TUNEL细胞凋亡检测,比较分析术前和术后心肌细胞凋亡率并参照围手术期肌钙蛋白T(cTnT)检测。【结果】两组患者均无低心输出量综合征的发生。心肌细胞凋亡指数A组(0.003±0.002)和B组(0.004±0.003)术前无明显差别(P〉0.05);术后心肌细胞凋亡指数A组(0.012±0.008,P〈0.001)和B组(0.006±0.004,P〈0.001)均高于术前;A、B两组术后心肌细胞凋亡指数差别有明显差别(P〈0.05)。围手术期cTnT水平A组在CPB末和术后2 h明显高于B组(P〈0.05)。【结论】本实验提示不停跳体外循环心内直视手术引起心肌细胞凋亡和心肌损害小于停跳手术。 [ Objective ] To investigate cardiomyocytes apoptosis in beating heart surgery with extra-corporeal circulation and to evaluate its clinical value. [Methods] Cardiomyocytes apoptosis were detected by TUNEL methods, perioperative cTnT level were record and compared between before and after the open heart surgery in the arrested heart surgery group 25 cases (Group A) and beating heart surgery group 20 cases (Group B). [Results] There were no low-output syndrome in both two groups. Cardiomyocytes apoptosis index has no difference between Group A (0.003±0.002) and Group B (0.004±0.003) preoperatively (P 〉0.05), the postoperative apoptosis index were significantly higher than those of preoperative in both Group A (0.012±0.008, P〈 0.001) and Group B (0.006± 0.004,P〈 0.001). Postoperative apoptosis index in Group A was higher statistically significant (P〈 0.05). Perioperative cTnT detection revealed a higher level in Group A than in Group B only at the point of CPB end and 2 hours after operation. [Conclusion] These results suggested that beating heart surgery has less implication in cardiomyocytes apoptosis than the conventional arrested heart surgery.
作者 熊利华 黄景彬 魏益平 李佳 祝曙光 华平 王铭辉 张华 XIONG Li-hua, HUANG Jing-bin, WEI Yi-ping, LI Jia, ZHU Shu-guang, HUA Ping, WANG Ming-hui, Zhang Hua ( 1. Department of Cardiothoracic Surgery, SUN Yat-sen Memorial Hospital, SUN Yat-sen University, Guangzhou 510120, China; 2. Department of Cardiothoracic Surgery; Liuzhou People Hospital//The Fifth Affiliated Hospital of Guangxi Medical University, Liuzhou 545001, China; 3. Research Institute of Cardiovascular Disease University of Hong Kong, Hong Kong, China )
出处 《中山大学学报:医学科学版》 CAS CSCD 北大核心 2007年第5期 562-564,569,共4页 Journal of Sun Yat-Sen University:Medical Sciences
基金 广东省自然科学基金(6021339)
关键词 不停跳心脏手术 心肌细胞 细胞凋亡 肌钙蛋白T beating heart surgery cardiomyocyte apoptosis cTnT
作者简介 熊利华(1955-),男,江西南昌人,教授,博士生导师,E-mail:Lihua21l@hotmail.com
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参考文献11

  • 1ATHANASULEAS C, SILER W, BUCKBERG G, et al. Myocardial protection during surgical ventricular restoration [J]. Eur J Cardiothorac Surg, 2006, 29 (1): S231- S237. 被引量:1
  • 2QUANIERS J M, LERUTH J, ALBERT A, et al. Comparison of inflammatory responses after off-pump and on-pump coronary surgery using surface modifying additives circuit [J]. Ann Thorac Surg, 2006, 81(5): 1683-1690. 被引量:1
  • 3COLUCCI W S. Apoptosis in the heart [J]. New Engl J Med, 1996, 335(16):1224-1226. 被引量:1
  • 4FLISS H, GATrING D. Apoptosis in ischemic and reperfused rat myocardium [J]. Circ Rec, 1996, 79(5): 949-956. 被引量:1
  • 5SCHMITr J P, SCHRODER J, SCHUNKERT H. Role of apoptosis in myocardial stunning after open heart surgery[J]. Ann Thorac Surg, 2002, 73(4):1229-1235. 被引量:1
  • 6MALMBERG M, VAHASILTA T, SARASTE A, et al. Cardiomyocyte apoptosis and duration of aortic clamping in pig model of open heart surgery [J]. Eur J Cardiothorac Surg, 2006, 30(3): 480-484. 被引量:1
  • 7田素民,李国营,李洁,于连发,郭志坤.不同时段的心肌缺血后再灌注损伤与心肌细胞凋亡的实验研究[J].解剖学研究,2003,25(2):97-99. 被引量:2
  • 8KAPLON R J, PHAM S M, SALERNO T A. Beatingheart valvular surgery: a possible alternative for patients with severely compromised ventricular function[J]. Card Surg, 2002, 17(2):170-172. 被引量:1
  • 9熊利华,苏艳玲,华平,陈炬,潘越江,张惠忠,张华,黄石辉.不停跳心内直视手术的临床研究[J].中山大学学报:医学科学版,2004,25(B07):221-223. 被引量:9
  • 10MASAKI M, IZUMI M, OSHIMA Y, et al. Smad1 protects cardiomyocytes from ischemia -reperfusion injury[J]. Circulation, 2005, 111(21):2752-2759. 被引量:1

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