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应激诱发复吸的动物模型及其神经生物学基础 预览 被引量:2

The Animal Model of Stress-induced Relapse and Its Neurobiological Mechanisms
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摘要 复吸是药物成瘾的重要特征,应激是诱发复吸的因素之一。该文介绍了用于研究应激诱发复吸的动物恢复模型,阐述了涉及应激诱发复吸的神经生物学基础。大量研究结果表明,下丘脑外侧的终纹床核与杏仁核内的促肾上腺皮质激素释放因子和去甲肾上腺素是参与应激诱发复吸的重要神经递质。内侧前额叶皮层可能是介导应激、药物点燃及药物相关线索等各类因素诱发复吸的共同通路。 Relapse is a major characteristic of drug addiction disorders and it has been well established that stress induces reinstatement of drug seeking in the animal model of relapse. This article first briefly describes several animal models that have been used to study the reinstatement of drug seeking induced by stress. Then it reviews evidence from studies concerned with the neurobiological mechanisms involved in stress-induced reinstatement of drug seeking. The results of these studies suggest an important role of the brain corticotrophin-releasing factor (CRF) and noradrenaiine (NA) neurons of the amygdala and the bed nucleus of the stria terminaiis (BNST) in the modulation of stress-induced reinstatement. The medial prefrontal cortex (mPFC) region may be a common pathway for cue, drug and stress-induced reinstatement of drug seeking.
作者 于斌 王佳 李新旺 Yu Bin, Wang Jia, Li Xinwang (Department of Psychology, Capital Normal University, Beijing 100089, China)
出处 《心理科学进展》 CSSCI CSCD 北大核心 2006年第1期 99-104,共6页 Advances In Psychological Science
基金 本研究得到北京市重点学科(发展与教育心理学)及北京市重点实验室(学习与认知)的资助.
关键词 复吸 应激 恢复模型 促肾上腺皮质激素释放因子 去甲肾上腺素 relapse, stress, reinstatement model, corticotrophin-releasing factor (CRF), noradrenaline (NA).
作者简介 通讯作者:李新旺.E-mail:pro_xwli@yahoo.com.cn,电话:(010)6890169l
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