Objective To investigate the changes of TNFa and IL - 8 with CPB of congenital heart disease combined with pulmonary hypertension.Methods 40 patients with left-to-right shunt of congenital heart disease divided into non-pulmonary hypertension group and pulmonary hypertension group. The levels of two group TNFa and IL-8 were compared after opening ascending aorta 1,2,4,6h. Results After CPB, the levels of TNFa and IL-8 were higher than preoperation （P 〈 0.05）,in pulmonary hypertension group the levels were significantly higher than that of the next one （P 〈 0.05）. Conclusion TNFa and IL-8 increase in CPB and the pulmonary hypertension is higher than in non-pulmonary hypertension group.
Journal of Henan Medical College For Staff and Workers
tumor necrosis factor a
congenital heart disease