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肿瘤坏死因子和白介素-8在先心病体外循环期的变化 预览 被引量:1

Changes of Tumor Necrosis Factor and Interleukin-8 with Cardiopulmonary Bypass of Congenital Heart Disease
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摘要 目的探讨肿瘤坏死因子和白介素-8在先心病合并肺动脉高压体外循环期的变化特点.方法将40例左向右分流的先心病患者分为非肺动脉高压组与肺动脉高压组.比较两组开放升主动脉后的1、2、4、6 h肿瘤坏死因子和白介素-8的水平.结果体外循环后,两组的肿瘤坏死因子和白介素-8水平均高于术前水平(P<0.05),而肺动脉高压组明显高于非肺动脉高压组(P<0.05).结论体外循环使肿瘤坏死因子和白介素-8合成增加,合并肺动脉高压者高于无肺动脉高压者. Objective To investigate the changes of TNFa and IL - 8 with CPB of congenital heart disease combined with pulmonary hypertension.Methods 40 patients with left-to-right shunt of congenital heart disease divided into non-pulmonary hypertension group and pulmonary hypertension group. The levels of two group TNFa and IL-8 were compared after opening ascending aorta 1,2,4,6h. Results After CPB, the levels of TNFa and IL-8 were higher than preoperation (P 〈 0.05),in pulmonary hypertension group the levels were significantly higher than that of the next one (P 〈 0.05). Conclusion TNFa and IL-8 increase in CPB and the pulmonary hypertension is higher than in non-pulmonary hypertension group.
作者 白希玲 BAI Xi-ling ( Henan Provincial Chest Hospital, Zhengzhou Henan 450003, China )
机构地区 河南省胸科医院
出处 《河南职工医学院学报》 2005年第6期 330-331,共2页 Journal of Henan Medical College For Staff and Workers
关键词 肿瘤坏死因子 白介素-8 先天性心脏病 肺动脉高压 tumor necrosis factor a interleukin-8 congenital heart disease pulmonary hypertension
作者简介 白希玲(1962-),女,黑龙江省绥棱县人,学士,副主任医师,从事小儿科临床工作.
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参考文献5

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