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何首乌对Alzheimer病大鼠学习记忆及乙酰胆碱酯酶的作用 预览 被引量:8

The effcet of PMEG on learning and memory ability and activity of AchE in AD rat
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摘要 目的探讨右侧海马注射β-淀粉样蛋白(Aβ)对大鼠学习记忆能力和乙酰胆碱酯酶(AchE)的影响及何首乌的作用.方法将Aβ1-40 10μg/μl 注入右侧海马建立大鼠AD模型,测定其学习记忆能力和脑AchE活性及何首乌的影响作用.结果 Aβ注射后出现较持久的学习记忆障碍,Aβ组呈渐进性加重,治疗组有一定的改善.Aβ组海马区、额叶皮质和基底前脑区的AchE的活性较对照组明显减少;治疗组较对照组减少,但较Aβ组有明显提高.结论何首乌能改善AD模型大鼠学习记忆获得能力,提高AchE活性. Objective To investigate whether amyloid-beta protein injected into hippocampus might affect memory ability and activity of acetylcholinesterase in rats,and the effects of Radix Polygonum Multiflorum Thumb(PMT). Methods The AD rat model was established by injection of amyloid-beta protein (Aβ1-40,10μg) into right hippocampus of rats. Learning and memory ability,the brain acetylcholinesterase activity were studied. Possible protective effects of Radix Polygoni Multiflori Preparata were also observed. Results Learning and memory disorder aggravated progressively in experimental group and ameliorated. Obviously in PMEG-administrated group at the 20th day. AchE activity in hippocampus,Meynert nucleus and cortex fields decreased remarkablely in experimental group,and that in PMEG-administrated group reduced obviously than in control group,but higher than in experimental group. Conclusion PMEG showes good activity,and can improve the activity of AchE.
作者 周琳 杨期东 马志健 袁梦石 候德仁 谭兴林 杜小平 ZHOU Lin,YANG Qi-dong,MA Zhi-jian,et al. (Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China)
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2004年第5期 394-396,共3页 Journal of Apoplexy and Nervous Diseases
基金 湖南省中医药管理局科研项目
关键词 大鼠 何首乌 学习记忆能力 乙酰胆碱酯酶 AD模型 对照组 脑区 基底前脑 海马区 Radix Polygons Multiflors Preparata (PMEG) Alzheimer’s disease Rat model β-amyloid peptide Acetylcholinesterase
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