In order to investigate the relationship between the cytoprotective mechanism of metallothione (MT) and its effect on endothelin (E T) , the model of rat torniq uet shock was produced. It was found that the treatment with MT significantly im proved animal shock stale, and inhibited the increase in plasma ET level of shocked rats. It was also observed that in vitro MT markedly antagonized ET-induced vasocontrac-tion and lowered angiotensin Ⅱ-stimulated release of ET in a dose-dependent manner. Tihe resulis suggest that MT could exert its injury-resistant action, as an endogenous defensive substance through inhibition of ET release and anlagonization against ET-induced vasocontraction.
Basic Medical Sciences and Clinics
metallothionein endothelin ischemia-reperf usion torniquet shook