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基于北京市儿童川崎病6年流行病学资料的实验室指标分析 预览 被引量:13

Analysis of the laboratory study indices based on the epidemiological data of the children with Kawasaki disease in Beijing in six years
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摘要 目的川崎病(KD)缺乏特异性诊断方法,部分患儿为不完全性KD临床表现,本文拟对KD患儿实验室检查指标中的ESR、CRP、PLT、血浆白蛋白(ALB)、ALT、Hb和WBC进行分析,探讨各项实验室指标异常协助临床诊断的意义及与冠状动脉损害和IVIG抵抗的关系。方法根据KD的诊断标准,对北京小儿川崎病流行病学调查协作组45家医院2000至2005年收治的急性期KD患儿的实验室资料进行汇总,将各指标同冠状动脉损害和IVIG抵抗行Pearson卡方检验和Logistic回归分析。结果共收集KD患儿1 745例,依据纳入和排除标准有1 335例进入分析,其中男868例,女467例。本组患儿ESR、CRP、PLT和WBC增高,ALB减低和Hb降低的发生率分别为96.0%、90.0%、92.2%和80.4%,45.7%和48.8%。Hb降低的发生率在不同的年龄组中存在明显差异,ALB和Hb降低与冠状动脉损害有相关性(P(0.05),CRP、ALB、ALT、Hb和WBC计数与IVIG抵抗有相关性(P(0.05)。Logistic回归显示ALB、Hb降低与冠状动脉损害有相关性,CRP升高、Hb降低、ALT和WBC升高与IVIG... Objective Up to now,there has been no gold test for the diagnosis of Kawasaki disease(KD).Some children might present as incomplete KD.This study sought to perform a statistical description for erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),platelet count(PLT),plasma albumin(ALB),alanine transaminase(ALT),hemoglobin(Hb),leukocyte count(WBC) and discuss the relationships among these laboratory indices and coronary ectasia and KD non-responder,respectively.Methods A questionnaire form and the 5th...
作者 鲁炜慧 杜忠东 赵地 杜军保 鲁珊 阎宗荣 衣京梅 候安存 周忠蜀 丁国芳 Beijing Kawasaki Disease Cooperative Research Group:LU Wei-hui1; DU Zhong-dong1; ZHAO Di2; DU Jun-bao3; LU Shan4; YAN Zong-rong5; YI Jing-mei6; HOU An-cun7; ZHOU Zhong-shu8; DING Guo-fang9(1 Department of Cardiology; Beijing Children s Hospital; Capital Medical University; 2 Department of Cardiology; Capital Institute of Pediatrics; 3 Department of Pediatrics; First Hospital of Peking University; 4 Department of Pediatrics; The Third Hospital of Peking University; 5 Department of Pediatrics; Liangxiang Hospital; Fangshan Distr...;
出处 《中国循证儿科杂志》 CSCD 2008年第5期,共6页 Chinese JOurnal of Evidence Based Pediatrics
基金 首都医学发展基金重点项目支持项目:2007-2063 首都医科大学基础临床联合项目:2007JL48
关键词 川崎病 实验室检查 冠状动脉损害 IVIG抵抗 Kawasaki disease Laboratory study indices Coronary impairment IVIG non-respond
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参考文献21

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