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改良B-Lynch缝合联合缩宫素治疗产后出血的疗效及对产妇血清NO、NOS、BNP的影响

Curative effect of modified B-Lynch suture combined with oxytocin on postpartum hemorrhage and influences on maternal serum NO,NOS and BNP
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摘要 目的:探究在治疗产后出血时联合使用改良B-Lynch缝合与缩宫素治疗疗效及对产妇血清NO、NOS、BNP水平的影响。方法:回顾性分析2015年4月~2019年4月期间80例在我院进行分娩产后出血产妇治疗资料,依据产妇产后出血治疗方式不同将接受缩宫素与改良B-Lynch缝合联合缩宫素止血患者分别归为对照组(n=36)和联合组(n=44)。比较两组产妇治疗效果,治疗前后血清NO、NOS、BNP水平,疗效相关时间并发症发生率。结果:联合组和对照组产妇治疗总有效率分别为93.18%和72.22%,前者治疗总有效率显著高于后者;两组产妇治疗后血清NO、NOS、BNP水平较治疗前显著降低,治疗后联合组患者上述指标水平低于对照组,差异具有统计学意义;联合组产妇止血时间、出血症状完全消失时间、治疗后血性恶露持续时间以及住院时间均显著低于对照组产妇;联合组产妇宫腔感染、贫血以及子宫切除等并发症发生率均低于对照组,差异具有统计学意义,而两组间发热以及宫腔形态异常等并发症发生率差异不显著。结论:改良B-Lynch缝合联合缩宫素可有效治疗产后出血,下调产妇血清NO、NOS、BNP水平,临床应用价值较高。 Objective To investigate the curative effect of modified B-Lynch suture combined with oxytocin on postpartum hemorrhage and influences on maternal serum NO,NOS and BNP.Methods A retrospective analysis was performed on treat-ment data of 80 postpartum hemorrhage puerperae who gave birth in the hospital from April 2015 to April 2019.According to different treatment methods for postpartum hemorrhage,patients given oxytocin or modified B-Lynch suture combined with oxytocin were included in control group(n=36)and combination group(n=44).The curative effect,levels of serum NO,NOS and BNP before and after treatment,related time of curative effect,and incidence of complications were compared between the two groups.Results The total response rates of treatment in combination group and control group were 93.18%and 72.22%,respectively.The above index of the former was significantly higher than that of the latter.After treatment,levels of serum NO,NOS and BNP in both groups were significantly decreased.After treatment,levels of the above indexes in combination group were lower than those in control group.The hemostasis time,complete disappearance time of bleeding symptoms,duration of bloody lochia after treatment,and hospitalization time in combination group were significantly lower than those in control group.The incidence of complications such as uterine infection,anemia and hysterectomy in combination group was lower than that in control group.There was no significant difference in incidence of complications such as fever or abnormal uterine cavity shape between the two groups.Conclusion Modified B-Lynch suture combined with oxytocin can effectively treat postpartum hemorrhage,down-regulate levels of serum NO,NOS and BNP,with relatively higher clinical application value.
作者 马春莲 乔发敏 Ma Chun-lian;Qiao Fa-min(Department of Obstetrics and Gynecology,Guangyuan Third People’s Hospital,Guangyuan 628000,China;Central Neutron Hospital of Chaotian District,Guangyuan 628000,China)
出处 《湖南师范大学学报:医学版》 2020年第3期153-156,共4页 Journal of Hunan Normal University(Medical Sciences)
关键词 改良B-Lynch缝合 缩宫素 产后出血 疗效 血清指标 modified B-Lynch suture oxytocin postpartum hemorrhage curative effect serum index
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